Royal Air Force Typhoon FGR4s have joined forces with French warplanes in a combined operation against an underground arms cache in Syrian territory employed by the IS group, according to the British defence ministry.
The facility, located using intelligence, was thought to be storing arms and explosives, the release indicated, and was located in mountains just north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized precision-guided Paveway IV munitions to strike a number of entry passages down to the facility... early reports are that the objective was successfully hit," the MoD said.
There was no sign of any civilian impact in the strike on Saturday evening and all the aircraft returned to base without incident, the MoD added.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
The Islamic State group - also known as ISIS - enforced jihadist rule over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This action underscores our UK leadership, and determination to stand shoulder to shoulder with allied nations, to eliminate any revival of IS and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the minister stated.
British military aircraft have carried out surveillance missions over Syria to "forestall any efforts to regroup" of the group after its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of our armed forces who took part in this strike for their professionalism and their valour," the Defence Secretary said. "They were among thousands of UK service members stationed over Christmas and New Year. This action, to eliminate militants who pose a risk to our security, highlights how British military are ready to step up, throughout the year, protecting the UK at home and strong abroad."
In December, the US military carried out what it termed a "massive strike" against Islamic State objectives in Syria, after an attack resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The UN says Islamic State still maintains an estimated 5,000 to 7,000 combatants in Iraq and Syria.